The best Side of fentanyl in pregnancy
The best Side of fentanyl in pregnancy
Blog Article
ribociclib will boost the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
iloprost, fentanyl. Possibly will increase effects of your other by pharmacodynamic synergism. Modify Therapy/Observe Carefully. When administering iloprost IV, consider temporary discontinuation of concomitant vasodilators or other medications that cut down blood pressure to mitigate potential additive hypotensive effects.
nafcillin will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to the decrease in fentanyl plasma concentrations, insufficient efficacy or, perhaps, growth of a withdrawal syndrome in the affected individual who has made Bodily dependence to fentanyl.
Important: Overdose warning Tend not to apply additional than one patch at a time, unless your medical doctor lets you know to. Using a lot more patches than suggested may lead to a fatal overdose.
Keep an eye on Intently (1)fentanyl will enhance the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
lenacapavir will improve the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
fentanyl, triprolidine. Both improves toxicity with the other by pharmacodynamic synergism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with anticholinergics may possibly boost risk for urinary retention and/or extreme constipation, which can bring about paralytic ileus.
asenapine transdermal and fentanyl both equally increase sedation. Avoid or Use Alternate Drug. Restrict use to patients for whom alternate treatment options are insufficient
nalbuphine decreases effects of fentanyl by pharmacodynamic antagonism. Prevent or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics might decrease fentanyl's analgesic effect And perhaps precipitate withdrawal symptoms.
isavuconazonium sulfate will enhance fentanyl bioavailability the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
omaveloxolone will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Omaveloxolone could minimize systemic exposure of sensitive CYP3A4 substrates. Examine prescribing information of substrate if dosage modification is required.
sotorasib will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. If use is unavoidable, confer with the prescribing information on the CYP3A4 substrate for dosage modifications
The preclinical data reviewed higher than support the check out which the pharmacology of fentanyl differs from other mu opioid agonists including morphine. In distinction, it is unclear if the pharmacology of fentanyl in humans since it pertains to abuse liability
Coadministration of encorafenib with delicate CYP3A4 substrates may well cause amplified toxicity or diminished efficacy of these agents.